Combined therapeutic use of oral alitretinoin and narrowband ultraviolet-B therapy in the treatment of Hailey-Hailey disease

Combined Therapeutic Use of Oral Alitretinoin and Narrowband Ultraviolet-B Therapy in the Treatment of Hailey-Hailey Disease

Hailey-Hailey disease (HHD) is a chronic familial bullous disease characterized by recurrent blisters and erosions typically at friction-prone areas of the body accompanied by acantholysis upon histologic examination. There are a number of therapies used in the management of HHD. Its symptoms have been effectively treated with antimicrobial therapies, corticosteroids and other agents such as cy...

The coexistence of Darier’s disease and Hailey-Hailey disease symptoms

Refractory Hailey-Hailey Disease That Responded Well to Photodynamic Therapy.

of vascular origin. The most important differential diagnoses are angiosarcoma, which expresses endothelial markers such as CD31 and CD34, and chronic expansive hematoma, which presents as an encapsulated tumor filled with blood and neovasculature. What was interesting about this case, apart from the rarity of the condition, was the ease with which a giant vascular eccrine spiradenoma could be ...

Bullous Darier’s disease mimicking Hailey-Hailey disease

BACKGROUND The bullous variant of Darier's disease (DD) is a rare type characterized by histological and clinical overlap with Hailey-Hailey disease (HDD). CASE REPORTS The following case report describes two cases of familial DD; a 51-year-old woman who presented with erythematous plaques, covered by small blisters in axillary and inguinal areas, and the first patient's daughter, who present...

Darier disease and Hailey-Hailey disease.

Darier disease (DD) and Hailey-Hailey disease (HHD) are autosomal dominantly inherited genodermatosis, caused by mutations in ATP2A2 gene and ATP2C1 respectively. We investigated clinical and laboratory two patients - a men with Darier disease and a woman with Hailey-Hailey disease. The patient with Darier disease has mucosal lesions and dental modifications associated with mild mental retardat...